Tag Archives: Christina Warinner

Microbes and You

(Note: The following is a news release from the University of Oklahoma)

Norman, Okla.—University of Oklahoma anthropologists are studying the ancient and modern human microbiome and the role it plays in human health and disease.  By applying genomic and proteomic sequencing technologies to ancient human microbiomes, such as coprolites and dental calculus, as well as to contemporary microbiomes in traditional and industrialized societies, OU researchers are advancing the understanding of the evolutionary history of our microbial self and its impact on human health today.

Dr. Christina Warinner

Dr. Christina Warinner

Christina Warinner, professor in the Department of Anthropology, OU College of Arts and Sciences, will present, “The Evolution and Ecology of Our Microbial Self,” during the American Association for the Advancement of Science panel on Evolutionary Biology Impacts on Medicine and Public Health, at 1:30 pm, Sunday, Feb. 14, in the Marriott Marshall Ballroom West, Washington, DC.  Warinner will discuss how major events, such as the invention of agriculture and the advent of industrialization, have affected the human microbiome.

“We don’t have a complete picture of the microbiome,” Warinner said. “OU research indicates human behavior over the past 2000 years has impacted the gut microbiome.  Microbial communities have become disturbed, but before we can improve our health, we have to understand our ancestral microbiome.  We cannot make targeted or informed interventions until we know that.  Ancient samples allow us to directly measure changes in the human microbiome at specific times and places in the past.”

Warinner and colleague, Cecil M. Lewis, Jr., co-direct OU’s Laboratories of Molecular Anthropology and Microbiome Research and the research focused on reconstructing the ancestral human oral and gut microbiome, addressing questions concerning how the relationship between humans and microbes has changed through time and how our microbiomes influence health and disease in diverse populations, both today and in the past.  Warinner and Lewis are leaders in the field of paleogenomics, and the OU laboratories house the largest ancient DNA laboratory in the United States.

Warinner is pioneering the study of ancient human microbiomes, and in 2014 she published the first detailed metagenomics and metaproteomic characterization of the ancient oral microbiome in the journal Nature Genetics.  In 2015, she published a study on the identification of milk proteins in ancient dental calculus and the reconstruction of prehistoric European dairying practices.  In the same year, she was part of an international team that published the first South American hunter-gatherer gut microbiome and identified Treponema as a key missing ancestral microbe in industrialized societies.

Warinner has published 17 peer-reviewed journal articles, 2 books, and 5 book chapters, and she serves on the Editorial Board of Scientific Reports.  Her research earned an Honorable Mention for the Omenn Prize, an annual prize for best article published on evolution, medicine and public health; and her ancient microbiome findings were named among the top 100 scientific discoveries of 2014 by Discover Magazine.

Warinner’s research has been featured in more than 75 news articles, including stories in Science, Cell, Scientific American, The New Scientist, Archaeology Magazine, the LA Times, the Guardian, WIRED UK, MSNBC, FOX News, and CNN, among others.  She has presented before the Royal Society of London and on behalf of the Leakey Foundation, and in 2015 she was invited to participate in a White House microbiome innovation forum sponsored by the Office of Science and Technology Policy.  She has been featured in two documentaries, and her current work on ancient Nepal appears in the award-winning children’s book, Secrets of the Sky Caves.

Warinner was named a U.S. National Academy of Sciences Kavli Fellow in 2014, and she was awarded a TED Fellowship in 2012.  Her TED Talks on ancient dental calculus and the evolution of the human diet have been viewed more than 1.5 million times.  For more information on Warinner’s AAAS presentation on the “Evolution and the Ecology of the Microbial Self,”

Ancient Dental Plaque

A University of Oklahoma scientist is perfecting the art (and by art I mean science) of studying ancient dental plaque. We’ve highlighted Dr. Christina Warinner before when her research gained national recognition. Now she’s featured in a fantastic video produced by Illumina. The company describes itself as, “a leading developer, manufacturer, and marketer of life science tools and integrated systems for large-scale analysis of genetic variation and function.” 

Dr. Warinner likes to say she’s an “archaeologist of the invisible”. She studies the dental plaque from teeth that are thousands of years old. Bacteria covers that dental plaque, from that she’s able to learn all kinds of things about the person who once used that tooth. Where they lived, what they ate, whether they were healthy or not, etc…

This video is an amazing look inside the process.

Medieval Dental Plaque Gets OU Researcher Top Honors

Research conducted by a University of Oklahoma anthropology professor has been named one of the top 100 stories of the year by Discover Magazine.

Christina Warinner directed a study of dental plaque from four Medieval skeletons. She published her research in Nature this past February. Discover Magazine was so impressed it’s ranked it the 69th best science story of the year and will feature it in an article in its January/February issue of the top 100 stories of of 2014.

According to OU, Warinner’s study found evidence of ancient DNA from wheat, pork, mutton, and a plant belonging to the mustard family. She also found ancient protein from cattle, sheep, and goat milk.

 

courtesy: University of Oklahoma

Photo credit: Malin Holst, courtesy: University of Oklahoma

The picture above shows a human jawbone that dates to the 1st-4th century from York, UK. Dr. Warinner doesn’t know the sex but says the person was in their 20s or 30s when they died. You can clearly see the build-up of dental plaque on the teeth. Dr. Warinner says this particular example tested positive of milk proteins.

Warinner wrote an article for CNN in 2012 explaining what she does and why it’s so important. “By extracting DNA from ancient human bones, we can reconstruct the human genome at different times in the past and look for differences that might be related to adaptations, risk factors, or inherited diseases,” she wrote. Adding, “The aim is to better understand the evolutionary vulnerabilities of the human body so that we can better manage and improve our health in the future.”

Want more with some cool illustrations? Here she is giving a presentation at TED in 2012.